Preheat the oven to 350 degrees.
In a mixing bowl, combine box cake mix, pure pumpkin, melted butter, milk, eggs, pumpkin pie spice and vanilla extract. Whisk until mixed together and no lumps from the cake mix remain. Don’t overmix.
Prepare your cupcake pan by placing cupcake liners inside the cavities.
Scoop cupcake batter into liners, fillling 2/3 of the way to the top.
Bake for approximately 18 minutes or until toothpick comes out clean.